It has to be Zoned as Commercial if you intend on a business there. It can be Residential-Commercial, but its just like a Church, or a School, they are zoned Commercial, some are Commercal-Residential.
Then you need a Business License,Tax ID.
After that, your pretty much set up.

Seems that you need R5 zoning. Find a place and start working with the City Hall (Dept. of Building and Safety) officials. Get in the line to get permits, because it could take up to 6 months to get what you need. You would be working with a city inspector who will be overseeing the project if you want to make additions. The process is not easy and many people get frustrated. But it’s possible.